Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | FOS | P01100 | 1/20 | 0.48 |
| ▸ | JUN | P05412 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29545771 | 0.83 | ALDH1A1 (0.70) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL1521842 | 0.83 | ALDH1A1 (0.70) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL29506595 | 0.81 | MAPT (0.61) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL188686 | 0.81 | MAPT (0.61) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL1014833 | 0.80 | SMN1; SMN2 (0.59) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL28520505 | 0.79 | SMN1; SMN2 (0.68) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL18673593 | 0.79 | MAPT (0.51) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL28456249 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL5808541 | 0.76 | MEN1 (0.58) | ALDH1A1MAPTSYKLMNASMN1; SMN2 | |
| SCHEMBL7017546 | 0.75 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249968-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIDO[2,3-DJPYRIMIDIN-7(8H)-ONE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |