Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730548 | 1.00 | SNCA (0.47) | SNCATRPM8MAPTNPC1L3MBTL1 | |
| SCHEMBL30582799 | 1.00 | SNCA (0.47) | SNCATRPM8MAPTNPC1L3MBTL1 | |
| SCHEMBL2729939 | 0.81 | TRPM8 (0.73) | TRPM8MAPTNPC1SMN1; SMN2HPGD | |
| SCHEMBL31647405 | 0.81 | TRPM8 (0.68) | TRPM8NPC1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL30582834 | 0.81 | TRPM8 (0.68) | TRPM8NPC1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2729530 | 0.81 | TRPM8 (0.68) | TRPM8NPC1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2730232 | 0.81 | TRPM8 (0.49) | TRPM8MAPTNPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2730229 | 0.81 | TRPM8 (0.49) | TRPM8MAPTNPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2729533 | 0.81 | TRPM8 (0.68) | TRPM8NPC1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL30582813 | 0.81 | TRPM8 (0.49) | TRPM8MAPTNPC1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635572-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |