Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730611 | 0.95 | LMNA (0.45) | LMNAMAPTKDM4ENPSR1HPGD | |
| SCHEMBL2730225 | 0.91 | LMNA (0.47) | LMNAMAPTKDM4ENPSR1HPGD | |
| SCHEMBL2730710 | 0.89 | KDM4E (0.47) | LMNAMAPTKDM4ENPSR1KMT2A | |
| SCHEMBL10079940 | 0.86 | LMNA (0.43) | LMNAMAPTHPGDTSHRMAPK1 | |
| SCHEMBL2732046 | 0.84 | PTGS1 (0.43) | LMNAMAPTTSHRKMT2AMEN1 | |
| SCHEMBL2730709 | 0.82 | PTGS1 (0.47) | LMNAMAPTHPGDTSHRMAPK1 | |
| SCHEMBL2732451 | 0.81 | MAPT (0.47) | LMNAMAPTKDM4ENPSR1TSHR | |
| SCHEMBL2732508 | 0.81 | PTGS1 (0.45) | MAPTTSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL2730667 | 0.81 | NPC1 (0.47) | LMNAMAPTNPSR1HPGDMAPK1 | |
| SCHEMBL2729734 | 0.81 | LMNA (0.43) | LMNAMAPTHPGDTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052395-A1 | ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS | N. V. ORGANON (NL) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012052395-A1 | ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS | N. V. ORGANON (NL) | 2012-04-26 | — | — | WO | disclosed |