Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.71 |
| ▸ | MLYCD | O95822 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PTAFR | P25105 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11176654 | 0.87 | NPC1 (0.90) | NPC1RAB9AHSP90AA1MLYCDSMN1; SMN2 | |
| SCHEMBL8115111 | 0.85 | NPC1 (0.87) | NPC1RAB9AHSP90AA1MLYCDSMN1; SMN2 | |
| SCHEMBL3225126 | 0.85 | NPC1 (1.00) | NPC1RAB9AHSP90AA1MLYCDSMN1; SMN2 | |
| SCHEMBL27284919 | 0.85 | L3MBTL1 (0.61) | MLYCDTMEM97SIGMAR1 | |
| SCHEMBL2021484 | 0.85 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2HDAC1HDAC8 | |
| SCHEMBL9717433 | 0.83 | POLB (0.68) | NPC1RAB9AKDM4EPOLB | |
| SCHEMBL8160662 | 0.82 | DRD2 (0.66) | NPC1RAB9ASMN1; SMN2HDAC1HDAC8 | |
| SCHEMBL6258710 | 0.81 | NPC1 (0.60) | NPC1RAB9AHSP90AA1MLYCDSMN1; SMN2 | |
| SCHEMBL5725233 | 0.81 | NPC1 (0.73) | NPC1RAB9AHSP90AA1MLYCDHDAC1 | |
| SCHEMBL5254724 | 0.81 | NPC1 (0.55) | NPC1RAB9AHSP90AA1MLYCDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1012500-B | Process for preparing aryl hydroxamates | SQUIBB & SONS INC (US) | 1991-05-01 | — | — | CN | disclosed |