Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557090 | 0.90 | KDM4E (0.63) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL27371515 | 0.90 | LMNA (0.64) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL2560003 | 0.83 | RAB9A (0.54) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL14758306 | 0.83 | KDM4E (0.70) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL17107238 | 0.83 | RAB9A (0.70) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL2554108 | 0.83 | KDM4E (0.63) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL2562374 | 0.83 | RAB9A (0.59) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL18115530 | 0.82 | LMNA (0.71) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL2753301 | 0.82 | LMNA (0.71) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL9892895 | 0.81 | LMNA (0.63) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006956-A9 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024006956-A9 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024006956-A2 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-04 | — | — | WO | disclosed |