Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27323900 | 0.85 | CRBN (0.50) | IKZF2CRBN | |
| SCHEMBL27313591 | 0.85 | CRBN (0.50) | IKZF2CRBN | |
| SCHEMBL27313191 | 0.83 | CRBN (0.52) | IKZF2CRBN | |
| SCHEMBL27322231 | 0.76 | CRBN (0.55) | IKZF2CRBN | |
| SCHEMBL27324524 | 0.75 | IKZF2 (0.47) | IKZF2CRBN | |
| SCHEMBL27313210 | 0.72 | CRBN (0.51) | IKZF2CRBN | |
| SCHEMBL27322113 | 0.72 | CRBN (0.55) | IKZF2CRBNBRAFMAPK3MAPK1 | |
| SCHEMBL27315986 | 0.71 | CRBN (0.56) | IKZF2CRBN | |
| SCHEMBL27217151 | 0.71 | CRBN (0.60) | IKZF2CRBN | |
| SCHEMBL25817831 | 0.70 | HTR2A (0.49) | IKZF2CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054832-A1 | CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS | INNOVO THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |