Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27314372 | 1.00 | GRM4 (0.51) | GRM4HTR1AHTR2ADRD3GRM5 | |
| SCHEMBL27314347 | 0.89 | RAB9A (0.51) | GRM4GRM5TNKS2KDM4EKMT2A | |
| SCHEMBL27314345 | 0.89 | RAB9A (0.51) | GRM4GRM5TNKS2KDM4EKMT2A | |
| SCHEMBL28824301 | 0.86 | GRM5 (0.54) | GRM5TNKS2KDM4EKMT2AGAA | |
| SCHEMBL27314363 | 0.85 | USP30 (0.50) | GRM4HTR1AHTR2ADRD3GRM5 | |
| SCHEMBL27314359 | 0.85 | USP30 (0.50) | GRM4HTR1AHTR2ADRD3GRM5 | |
| SCHEMBL30746898 | 0.85 | USP30 (0.50) | GRM4HTR1AHTR2ADRD3GRM5 | |
| SCHEMBL30830988 | 0.82 | GRM5 (0.47) | GRM5TNKS2KDM4EKMT2AGAA | |
| SCHEMBL31091772 | 0.81 | GRM5 (0.50) | GRM5TNKS2KDM4EKMT2AGAA | |
| SCHEMBL28431573 | 0.80 | NPC1 (0.52) | GRM5TNKS2KDM4EKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024003533-A1 | PROTACS FOR TARGETED DEGRADATION OF KAT2A AND KAT2B FOR THE TREATMENT OF CANCER | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2024-01-04 | — | — | WO | disclosed |