Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.47 |
| ▸ | BPTF | Q12830 | 1/20 | 0.47 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28824301 | 0.83 | GRM5 (0.54) | BPTFKAT2AKAT2BGRM5KMT2A | |
| SCHEMBL28437697 | 0.82 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL31091772 | 0.82 | GRM5 (0.50) | BPTFKAT2AKAT2BGRM5KMT2A | |
| SCHEMBL27314347 | 0.80 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL27314345 | 0.80 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL27314372 | 0.80 | GRM4 (0.51) | NPC1RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL27314367 | 0.80 | GRM4 (0.51) | NPC1RAB9ASMN1; SMN2PKMLMNA | |
| SCHEMBL30830988 | 0.79 | GRM5 (0.47) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL30200058 | 0.77 | GRM5 (0.62) | SMN1; SMN2ALDH1A1L3MBTL1GRM5KMT2A | |
| SCHEMBL7986175 | 0.71 | GRM5 (0.72) | RAB9ASMN1; SMN2MAPTGRM5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499639-B | Pyrimidone derivatives and their use in pharmacy | 四川大学华西医院 | 2022-03-04 | — | — | CN | disclosed |
| CN-111499639-A | Pyrimidone derivatives and their use in pharmacy | 四川大学华西医院 | 2020-08-07 | — | — | CN | disclosed |