Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27315615 | 0.87 | NTRK1 (0.58) | NTRK1NTRK2RET | |
| SCHEMBL27315227 | 0.84 | NTRK1 (0.55) | NTRK1NTRK2MAPK1KDRRET | |
| SCHEMBL1926377 | 0.83 | NTRK1 (0.85) | NTRK1NTRK2RAB9ANPC1MEN1 | |
| SCHEMBL27315176 | 0.83 | NTRK1 (0.55) | NTRK1NTRK2RAB9ANPC1MEN1 | |
| SCHEMBL27315205 | 0.80 | NTRK1 (0.54) | NTRK1NTRK2MAPK1KDRRET | |
| SCHEMBL27315059 | 0.80 | NTRK1 (0.56) | NTRK1NTRK2KDRRETAURKA | |
| SCHEMBL27315108 | 0.77 | NTRK1 (0.57) | NTRK1NTRK2KDRRETFGFR1 | |
| SCHEMBL708688 | 0.74 | AURKB (0.74) | NTRK1NTRK2RAB9ANPC1PKM | |
| SCHEMBL1924757 | 0.73 | NTRK1 (1.00) | NTRK1NTRK2MEN1KMT2AMAPK1 | |
| SCHEMBL1924006 | 0.73 | NTRK2 (1.00) | NTRK1NTRK2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611900-A1 | RET-LDD PROTEIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097980-A1 | RET-LDD PROTEIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |