Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27315264 | 0.81 | AXL (0.48) | MERTKAURKBAURKATYRO3AXL | |
| SCHEMBL27315170 | 0.80 | NTRK1 (0.57) | NTRK1NTRK2KDRRETMERTK | |
| SCHEMBL27315227 | 0.78 | NTRK1 (0.55) | NTRK1NTRK2KDRRETMERTK | |
| SCHEMBL27315615 | 0.78 | NTRK1 (0.58) | NTRK1NTRK2RET | |
| SCHEMBL27315176 | 0.78 | NTRK1 (0.55) | NTRK1NTRK2KDRRETMERTK | |
| SCHEMBL27315622 | 0.76 | NTRK1 (0.39) | NTRK1NTRK2RET | |
| SCHEMBL1925743 | 0.75 | NTRK1 (0.79) | NTRK1NTRK2KDRAURKBAURKA | |
| SCHEMBL27315108 | 0.74 | NTRK1 (0.57) | NTRK1NTRK2KDRRETCSNK2A2 | |
| SCHEMBL27315059 | 0.72 | NTRK1 (0.56) | NTRK1NTRK2KDRRETAURKA | |
| SCHEMBL1924757 | 0.70 | NTRK1 (1.00) | NTRK1NTRK2KDRRETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611900-A1 | RET-LDD PROTEIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097980-A1 | RET-LDD PROTEIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |