Thiophene

Thiophene

SCHEMBL27316624

N#Cc1ccc(C(F)(F)F)cc1.c1ccsc1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 4/20 0.66
CYP3A4 P08684 3/20 0.49
CYP3A5 P20815 2/20 0.49
PTPN5 P54829 1/20 0.41
CYP19A1 P11511 5/20 0.40
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALOX15 P16050 1/20 0.40
BRCA1 P38398 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
DGAT1 O75907 1/20 0.39
SOAT1 P35610 1/20 0.39
KCNH2 Q12809 1/20 0.39
VNN1 O95497 1/20 0.38
TSHR P16473 2/20 0.38
TRPM8 Q7Z2W7 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL524351 0.85 KIF11 (0.86) KIF11CYP3A4CYP3A5PTPN5CYP19A1
Hydrochloric Acid SCHEMBL27812058 0.83 KIF11 (0.83) KIF11CYP3A4CYP3A5PTPN5CYP19A1
SCHEMBL3456838 0.79 KIF11 (1.00) KIF11CYP3A4CYP3A5PTPN5CYP19A1
SCHEMBL16626137 0.79 KIF11 (0.76) KIF11CYP3A4CYP3A5PTPN5CYP19A1
SCHEMBL13063632 0.79 KIF11 (1.00) KIF11CYP3A4CYP3A5PTPN5CYP19A1
SCHEMBL4450175 0.76 KIF11 (0.75) KIF11CYP3A4CYP3A5PTPN5ALDH1A1
SCHEMBL11092767 0.76 KIF11 (0.63) KIF11CYP3A4CYP3A5PTPN5DGAT1
Benzonitrile SCHEMBL28171919 0.74 TSHR (0.70) ALDH1A1TSHRMAOB
SCHEMBL458229 0.74 KIF11 (0.68) KIF11CYP3A4CYP3A5PTPN5CYP19A1
SCHEMBL2119044 0.74 KIF11 (0.68) KIF11CYP3A4CYP3A5PTPN5CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1037436-C New herbicides RHONE POULENC AGRICULTURE (GB) 1998-02-18 CN disclosed
CN-1082539-A New herbicides RHONE POULENC AGRICULTURE (GB) 1994-02-23 CN disclosed