Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 4/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731632 | 0.84 | MAP2K4 (0.43) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL2731864 | 0.83 | MAP2K4 (0.49) | MAP2K4RORCGPR119USP30NAMPT | |
| SCHEMBL3632748 | 0.82 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL30356750 | 0.81 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21338406 | 0.81 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL26289606 | 0.81 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL25994433 | 0.74 | MAP2K4 (0.56) | MAP2K4RORC | |
| SCHEMBL4006762 | 0.73 | MAP2K4 (0.58) | MAP2K4RORCBTK | |
| SCHEMBL22801881 | 0.73 | MAP2K4 (0.50) | MAP2K4RORCNAMPT | |
| SCHEMBL3635142 | 0.73 | MAP2K4 (0.55) | MAP2K4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536319-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-09-11 | — | — | EP | disclosed |
| US-8999966-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130237518-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP | 2013-09-12 | — | — | US | disclosed |
| EP-2632268-A2 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058127-A2 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237518-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAP3K20 | GABRG2 3127/4885GABRB3 3338/4885GABRA5 4108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.