Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15312268 | 0.88 | GABRG2 (0.41) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL26289606 | 0.86 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL30356750 | 0.86 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21338406 | 0.86 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL3671675 | 0.86 | GABRA1 (0.40) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL9951676 | 0.84 | GABRG2 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL2731689 | 0.82 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL27810087 | 0.80 | GABRG2 (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL24358718 | 0.76 | GABRA1 (0.34) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL25218361 | 0.76 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8648069-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | GABRG2 4695/4885GABRB3 4209/4885GABRA5 4411/4885 |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | GABRG2 4695/4885GABRB3 4209/4885GABRA5 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.