Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.65 |
| ▸ | JAK2 | O60674 | 8/20 | 0.65 |
| ▸ | BRD4 | O60885 | 6/20 | 0.65 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.65 |
| ▸ | BRD2 | P25440 | 1/20 | 0.65 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.65 |
| ▸ | JAK1 | P23458 | 6/20 | 0.64 |
| ▸ | SRC | P12931 | 5/20 | 0.64 |
| ▸ | AXL | P30530 | 3/20 | 0.64 |
| ▸ | TYK2 | P29597 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | TEK | Q02763 | 3/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | MERTK | Q12866 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30427133 | 1.00 | JAK3 (0.65) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL30171204 | 0.90 | AXL (0.59) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL2723335 | 0.87 | JAK3 (0.61) | JAK3JAK2BRD4BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL2730396 | 0.86 | JAK3 (0.59) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL264158 | 0.82 | JAK3 (0.79) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL30381504 | 0.82 | JAK3 (0.79) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL20500090 | 0.81 | BRD4 (0.63) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL269996 | 0.81 | BRD4 (0.65) | JAK3JAK2BRD4BRDTBRD2 | |
| Hydrochloric Acid SCHEMBL265478 | 0.80 | BRD4 (0.64) | JAK3JAK2BRD4BRDTBRD2 | |
| SCHEMBL17907579 | 0.80 | BRD4 (0.66) | JAK3JAK2BRD4BRDTBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872161-A2 | METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF | Del Mar Pharmaceuticals (CA) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014004376-A2 | METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF | DEL MAR PHARMACEUTICALS (CA) | 2014-01-03 | — | — | WO | disclosed |
| EP-2635282-A1 | COMPOSITIONS AND METHODS FOR TREATING MYELOFIBROSIS | TargeGen, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2013059548-A9 | COMPOSITIONS AND METHODS FOR TREATING CANCER USING JAK2 INHIBITOR | SANOFI (FR) | 2013-06-06 | — | — | WO | disclosed |
| WO-2013059548-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER USING JAK2 INHIBITOR | SANOFI (FR) | 2013-04-25 | — | — | WO | disclosed |
| WO-2012061833-A1 | COMPOSITIONS AND METHODS FOR TREATING MYELOFIBROSIS | TARGEGEN, INC. (US) | 2012-05-10 | — | — | WO | disclosed |