Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.59 |
| ▸ | MERTK | Q12866 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 7/20 | 0.53 |
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.53 |
| ▸ | BRD2 | P25440 | 1/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731745 | 0.90 | JAK3 (0.65) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL30427133 | 0.90 | JAK3 (0.65) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL2723335 | 0.77 | JAK3 (0.61) | AXLMERTKBRD4JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL2730396 | 0.76 | JAK3 (0.59) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL21460538 | 0.74 | AXL (0.56) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL1035893 | 0.73 | GLO1 (0.68) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL30171152 | 0.73 | LMNA (0.41) | PTK2KDRROCK2ULK1CDK7 | |
| SCHEMBL30381504 | 0.72 | JAK3 (0.79) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL21460562 | 0.72 | AXL (0.49) | AXLMERTKBRD4JAK3JAK2 | |
| SCHEMBL12726404 | 0.72 | GLO1 (0.67) | AXLMERTKBRD4JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115745896-B | JAK2 kinase selective inhibitor and preparation method and application thereof | 合肥医工医药股份有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-115745896-A | JAK2 kinase selective inhibitor and preparation method and application thereof | 合肥医工医药股份有限公司 | 2023-03-07 | — | — | CN | disclosed |