Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.58 |
| ▸ | FEN1 | P39748 | 2/20 | 0.58 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.58 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005766 | 0.77 | ERCC1 (0.64) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL1894456 | 0.74 | FEN1 (1.00) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL2759479 | 0.73 | ERCC1 (0.58) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL14945700 | 0.72 | ERCC1 (0.49) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL14208214 | 0.72 | LMNA (0.37) | ERCC5FEN1LMNAMAPT | |
| SCHEMBL9097551 | 0.70 | DAO (0.42) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL4243895 | 0.70 | ERCC1 (0.54) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL7650487 | 0.69 | ADORA3 (0.61) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL29407350 | 0.69 | ADORA3 (0.61) | ERCC5FEN1ERCC1ERCC4ALDH1A1 | |
| SCHEMBL22041457 | 0.69 | ERCC5 (0.62) | ERCC5FEN1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | ERCC5 572/4885FEN1 926/4885ERCC1 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.