Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4EBP1 | Q13541 | 11/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554455 | 0.85 | ALDH1A1 (0.42) | EIF4EBP1KDM4EGPR35LCKSORT1 | |
| SCHEMBL22866767 | 0.83 | KDM4E (0.40) | KDM4E | |
| SCHEMBL29560113 | 0.83 | KDM4E (0.40) | KDM4E | |
| SCHEMBL28715107 | 0.83 | GPR35 (0.45) | EIF4EBP1KDM4EGPR35SORT1 | |
| SCHEMBL28704856 | 0.83 | EIF4EBP1 (0.41) | EIF4EBP1 | |
| SCHEMBL28704402 | 0.79 | EIF4EBP1 (0.54) | EIF4EBP1 | |
| SCHEMBL22866890 | 0.78 | HPGD (0.37) | KDM4EGPR35 | |
| SCHEMBL19698920 | 0.73 | GPR35 (0.41) | EIF4EBP1KDM4EGPR35 | |
| SCHEMBL28717584 | 0.71 | GPR35 (0.38) | KDM4EGPR35 | |
| SCHEMBL29560349 | 0.70 | PARP1 (0.39) | KDM4ESORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024103067-A1 | COMPOUNDS AND COMPOSITIONS AS eIF4E INHIBITORS AND USES THEREOF | RIBOMETRIX, INC. (US) | 2024-05-16 | — | — | WO | disclosed |
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |