Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.46 |
| ▸ | TP53 | P04637 | 11/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | XBP1 | P17861 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27407913 | 0.82 | NPC1 (0.34) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL18528954 | 0.79 | TP53 (0.46) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL2475444 | 0.79 | TP53 (0.64) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL10999199 | 0.77 | MAPT (0.39) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL27535755 | 0.76 | GABRP (0.42) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL6861984 | 0.74 | MAPT (0.43) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL27595971 | 0.74 | TDP1 (0.44) | MAPTALDH1A1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL31461745 | 0.72 | TP53 (0.49) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL23036862 | 0.72 | TP53 (0.43) | MAPTTP53TLR9NPC1ALDH1A1 | |
| SCHEMBL27652453 | 0.72 | TDP1 (0.38) | MAPTALDH1A1NPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |