SCHEMBL27322007

SCHEMBL27322007

CC1COC(c2cc(F)c(-c3cc(F)c(-c4cc(F)c(C#N)c(F)c4)c(F)c3)c(F)c2)OC1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 3/20 0.37
CYP11B2 P19099 3/20 0.37
TRPV4 Q9HBA0 1/20 0.34
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
KDM1A O60341 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9406923 0.91 TRPV4 (0.40) CYP11B1CYP11B2TRPV4
SCHEMBL9406918 0.91 TRPV4 (0.40) CYP11B1CYP11B2TRPV4
SCHEMBL15488942 0.87 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL15180939 0.84 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL30332276 0.83 CYP11B1 (0.32) CYP11B1CYP11B2TRPV4PDE4APDE4B
SCHEMBL13002705 0.79 CYP11B1 (0.33) CYP11B1CYP11B2
SCHEMBL14749542 0.79
SCHEMBL14235166 0.79
SCHEMBL15180942 0.78 CYP11B1 (0.34) CYP11B1CYP11B2
SCHEMBL9407073 0.78 TRPV4 (0.34) CYP11B1CYP11B2TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023232753-A1 FERROELECTRIC SMECTIC LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2023-12-07 WO disclosed
WO-2023232754-A1 FERROELECTRIC NEMATIC LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2023-12-07 WO disclosed