Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12485644 | 0.86 | CTSL (0.57) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL8799700 | 0.84 | EGFR (0.53) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL27423214 | 0.84 | EGFR (0.55) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL27338343 | 0.84 | CTSL (0.58) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL8798922 | 0.84 | EGFR (0.52) | EGFRTNNI3KPIK3CAPRKDCRAB9A | |
| SCHEMBL8798928 | 0.84 | EGFR (0.52) | EGFRTNNI3KPIK3CAPRKDCRAB9A | |
| SCHEMBL8804869 | 0.84 | EGFR (0.52) | EGFRTNNI3KPIK3CAPRKDCRAB9A | |
| SCHEMBL8315578 | 0.78 | EGFR (0.48) | EGFRFLT3TYRO3MERTKGAS6 | |
| SCHEMBL8315576 | 0.78 | EGFR (0.48) | EGFRFLT3TYRO3MERTKGAS6 | |
| SCHEMBL8315571 | 0.78 | EGFR (0.48) | EGFRFLT3TYRO3MERTKGAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |