Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12485644 | 0.85 | CTSL (0.57) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL27322786 | 0.84 | EGFR (0.54) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL8798751 | 0.84 | EGFR (0.51) | EGFRTNNI3KNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8798748 | 0.84 | EGFR (0.51) | EGFRTNNI3KNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27423214 | 0.83 | EGFR (0.55) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL27338343 | 0.83 | CTSL (0.58) | EGFRTNNI3KFLT3TYRO3MERTK | |
| SCHEMBL8799789 | 0.83 | EGFR (0.52) | EGFRTNNI3KNPC1RAB9APRKDC | |
| SCHEMBL8800460 | 0.83 | EGFR (0.55) | EGFRTNNI3KIRAK4 | |
| SCHEMBL8800238 | 0.80 | EGFR (0.47) | EGFRFLT3TYRO3MERTKGAS6 | |
| SCHEMBL8315077 | 0.78 | FLT3 (0.47) | EGFRFLT3TYRO3MERTKGAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |