Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27338346 | 0.85 | MEN1 (0.44) | MEN1KMT2AEGFRCTSLCTSB | |
| SCHEMBL27317919 | 0.84 | EGFR (0.49) | MEN1KMT2AMAPK1LMNAMAPK10 | |
| SCHEMBL27330845 | 0.83 | TNNI3K (0.54) | EGFRABCG2TNNI3K | |
| SCHEMBL27339277 | 0.83 | EGFR (0.45) | MEN1KMT2AEGFRERBB4RAB9A | |
| SCHEMBL27339286 | 0.82 | PRCP (0.49) | MEN1KMT2AEGFRERBB4RAB9A | |
| SCHEMBL27338340 | 0.81 | KCNQ3 (0.48) | MEN1KMT2AMAPK1HTTSMN1; SMN2 | |
| SCHEMBL27334593 | 0.80 | EGFR (0.41) | MEN1KMT2AEGFRERBB4RAB9A | |
| SCHEMBL27318731 | 0.80 | EGFR (0.47) | MEN1KMT2AHTTKDM4ELMNA | |
| SCHEMBL27345375 | 0.80 | MEN1 (0.69) | MEN1KMT2AMAPK1LMNAEGFR | |
| SCHEMBL27320738 | 0.80 | KDM1A (0.48) | EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |