Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27338346 | 0.86 | MEN1 (0.44) | EGFRCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL27338340 | 0.85 | KCNQ3 (0.48) | EGFRERBB3CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27344279 | 0.84 | MEN1 (0.45) | EGFRERBB3CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27323499 | 0.84 | MEN1 (0.51) | EGFRMAPK10MAPK1MEN1KMT2A | |
| SCHEMBL8799653 | 0.84 | ABL1 (0.56) | EGFRMAPK1MEN1KMT2AABL1 | |
| SCHEMBL27408590 | 0.81 | S1PR1 (0.42) | EGFRERBB3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27339283 | 0.81 | MEN1 (0.74) | EGFRERBB3MEN1KMT2AALDH1A1 | |
| SCHEMBL27339284 | 0.81 | GPR119 (0.42) | EGFRERBB3CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27317916 | 0.81 | TRPV1 (0.47) | EGFRCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL8798532 | 0.79 | KDR (0.46) | EGFRS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |