Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27324166 | 0.79 | ALDH1A1 (0.33) | ALDH1A1GAAKMT2ABCHECTSB | |
| SCHEMBL27324174 | 0.78 | ALDH1A1 (0.32) | ALDH1A1GAAKMT2ABCHECTSB | |
| SCHEMBL17972972 | 0.76 | GABRR1 (0.39) | ALDH1A1GAAKMT2A | |
| SCHEMBL23325006 | 0.75 | ACKR3 (0.32) | — | |
| SCHEMBL27324169 | 0.73 | CTSB (0.37) | CTSBCTSSCTSK | |
| SCHEMBL10202191 | 0.73 | BCHE (0.41) | BCHE | |
| SCHEMBL14188732 | 0.71 | SLC6A2 (0.44) | — | |
| SCHEMBL14076272 | 0.71 | SLC6A2 (0.44) | — | |
| SCHEMBL23269728 | 0.71 | SLC6A2 (0.35) | ALDH1A1BCHE | |
| SCHEMBL23269570 | 0.71 | SLC6A2 (0.35) | ALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081363-A1 | COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER | Revolution Medicines, Inc. (US) | 2024-04-18 | — | — | WO | disclosed |