Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PYGB | P11216 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14853201 | 0.86 | KMT2A (0.39) | TSHRMAPTMEN1NPC1RAB9A | |
| SCHEMBL12424435 | 0.86 | KMT2A (0.39) | TSHRMAPTMEN1NPC1RAB9A | |
| SCHEMBL15373215 | 0.86 | KMT2A (0.39) | TSHRMAPTMEN1NPC1RAB9A | |
| SCHEMBL24974001 | 0.84 | NFKB1 (0.42) | ALDH1A1MAPTGLAEPHX1 | |
| SCHEMBL16133589 | 0.82 | KMT2A (0.47) | TSHRMAPTMEN1NPC1RAB9A | |
| SCHEMBL5949738 | 0.82 | KMT2A (0.47) | TSHRMAPTMEN1NPC1RAB9A | |
| SCHEMBL20233119 | 0.81 | BTK (0.51) | ALDH1A1KMT2AEPHX1BTK | |
| SCHEMBL25957596 | 0.81 | BTK (0.51) | ALDH1A1KMT2AEPHX1BTK | |
| SCHEMBL12424476 | 0.81 | BTK (0.51) | ALDH1A1KMT2AEPHX1BTK | |
| SCHEMBL14631213 | 0.80 | ALDH1A1 (0.33) | ALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024123966-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |