Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532565 | 0.79 | GAA (0.56) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL25942185 | 0.77 | GAA (0.38) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17115087 | 0.76 | CHRM2 (0.39) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11918957 | 0.74 | CXCR4 (0.38) | GAAALDH1A1LMNA | |
| SCHEMBL16303842 | 0.73 | SMN1; SMN2 (0.42) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL25241729 | 0.71 | GAA (0.47) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL24799993 | 0.71 | ALDH1A1 (0.52) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL27325967 | 0.70 | SOS1 (0.41) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL16302793 | 0.70 | SOS1 (0.41) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL38664741 | 0.68 | KDM1A (0.40) | GAAALDH1A1KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024088922-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL) | F. HOFFMANN-LA ROCHE AG (CH) | 2024-05-02 | — | — | WO | disclosed |