Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13960166 | 0.83 | EPHX2 (0.43) | HPGDGAAFKBP1ADPP4KMT2A | |
| SCHEMBL4518874 | 0.81 | FKBP1A (0.40) | HPGDGAAFKBP1ADPP4HSD17B10 | |
| SCHEMBL27973416 | 0.81 | POLB (0.34) | HPGDGAAALDH1A1DPP4HSD17B10 | |
| SCHEMBL21319546 | 0.80 | CHRM2 (0.41) | DPP4 | |
| SCHEMBL15392569 | 0.79 | HPGD (0.37) | HPGDGAAFKBP1AALDH1A1MAPT | |
| SCHEMBL3798847 | 0.79 | EPHX2 (0.36) | GAAFKBP1AALDH1A1MAPTKMT2A | |
| SCHEMBL29424741 | 0.79 | EPHX1 (0.43) | HPGDFKBP1AALDH1A1HSD17B10KMT2A | |
| SCHEMBL18634637 | 0.79 | DPP4 (0.42) | DPP4 | |
| SCHEMBL5312094 | 0.78 | KMT2A (0.36) | HPGDGAAALDH1A1DPP4HSD17B10 | |
| SCHEMBL29588126 | 0.76 | HTT (0.37) | HPGDGAAALDH1A1DPP4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341379-A1 | INHIBITORS OF EZH2 | Eli Lilly and Company (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035060-A1 | INHIBITORS OF EZH2 | ELI LILLY AND COMPANY (US) | 2017-03-02 | — | — | WO | disclosed |
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |