Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27689582 | 0.81 | HTT (0.43) | HTTKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL15392569 | 0.80 | HPGD (0.37) | HTTHPGDALDH1A1GAAHSD11B1 | |
| SCHEMBL31722100 | 0.77 | HCRTR2 (0.40) | DPP4FAPDPP7 | |
| SCHEMBL20055272 | 0.76 | CHRM2 (0.39) | FAP | |
| SCHEMBL2732689 | 0.76 | HPGD (0.38) | SMN1; SMN2HPGDALDH1A1TSHRGAA | |
| SCHEMBL15414815 | 0.76 | RIPK1 (0.36) | HPGDALDH1A1GAAPOLBDPP4 | |
| SCHEMBL1128495 | 0.75 | EPHX1 (0.49) | SMN1; SMN2HPGDALDH1A1HSD17B10 | |
| SCHEMBL30443171 | 0.75 | CHRM2 (0.37) | HTTHPGDALDH1A1TSHRGAA | |
| SCHEMBL21293929 | 0.74 | DPP4 (0.40) | DPP4FAP | |
| SCHEMBL4955982 | 0.74 | BBOX1 (0.35) | POLBDPP4FAPDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478528-A | Aroyl-substituted tricyclic compound, preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2022-05-13 | — | — | CN | disclosed |