Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Metocinium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.72 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.72 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.72 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SCN1A | P35498 | 2/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metocinium SCHEMBL2108327 | 0.98 | CHRM2 (0.74) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| Methylbenactyzium SCHEMBL669744 | 0.85 | CHRM1 (0.97) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| Methylbenactyzium SCHEMBL60901 | 0.84 | CHRM1 (1.00) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| Methylbenactyzium SCHEMBL8816404 | 0.84 | CHRM1 (0.94) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| Lachesine SCHEMBL1946024 | 0.84 | CHRM1 (0.75) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| SCHEMBL11363962 | 0.83 | CHRM2 (0.55) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| SCHEMBL8309422 | 0.83 | CHRM2 (0.60) | CHRM2CHRM1CHRM3CHRM4SCN1A | |
| Lachesine SCHEMBL3638169 | 0.82 | CHRM1 (0.73) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| SCHEMBL11363241 | 0.82 | CHRM2 (0.57) | CHRM2CHRM1CHRM3CHRM4MEN1 | |
| Methylbenactyzium SCHEMBL8446490 | 0.81 | CHRM1 (0.95) | CHRM2CHRM1CHRM3CHRM4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 326 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119838022-A | Amatoxin conjugates containing branched linkers | 杭州多禧生物科技有限公司 | 2025-04-18 | — | — | CN | claimed |
| CN-119631882-A | Methods and compositions related to improved nitrogen utilization efficiency in tobacco | 奥驰亚客户服务有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119631883-A | Methods and compositions related to improved nitrogen utilization efficiency in tobacco | 奥驰亚客户服务有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119631884-A | Methods and compositions related to improved nitrogen utilization efficiency in tobacco | 奥驰亚客户服务有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-113490510-B | Cross-species single domain antibodies targeting mesothelin for the treatment of solid tumors | 美国政府(由卫生和人类服务部的部长所代表) | 2025-02-14 | — | — | CN | claimed |
| CN-118680958-A | Antibiotic, antipathogen adhesion, antioxidation and cell growth repair promoting metacin preparation, preparation method and application | 中国农业大学 | 2024-09-24 | — | — | CN | claimed |
| CN-118434765-A | BCMA monoclonal antibodies and antibody-drug conjugates | 杭州多禧生物科技有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-118215676-A | Specific conjugation of antibody drug conjugates | 杭州多禧生物科技有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-118141602-A | Lacrimal canaliculus embolism | 上海曙瑞科技有限公司 | 2024-06-07 | — | — | CN | claimed |
| CN-117980327-A | Specific coupling of antibodies | 杭州多禧生物科技有限公司 | 2024-05-03 | — | — | CN | claimed |
| CN-117085144-A | Ligand drug conjugate and application thereof | 成都百利多特生物药业有限责任公司 | 2023-11-21 | — | — | CN | claimed |
| CN-117063796-A | Double-coverage planting method for detoxified potato grass film | 甘肃农富联农业科技有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-116849114-A | Methods and compositions related to improved nitrogen utilization efficiency in tobacco | 奥驰亚客户服务有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115192535-B | Aminometacin enteric-coated tablet and preparation method thereof | 广东逸舒制药股份有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-116549351-A | Anti-wrinkle moisturizing essence and preparation method thereof | 康铂创想（北京）科技有限公司 | 2023-08-08 | — | — | CN | claimed |
| CN-111212562-B | Methods and compositions related to improved nitrogen utilization efficiency in tobacco | 奥驰亚客户服务有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-116143678-A | Conjugate linker, cell-binding molecule-drug conjugate containing the same, and preparation and application thereof | 杭州多禧生物科技有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-1599175-A2 | IMIDAZOPYRIDINES CONTAINING COMBINATIONS AND THEIR USE IN TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | ALTANA Pharma AG (DE) | 2005-11-30 | — | — | EP | claimed |
| WO-2005074930-A1 | PHARMACEUTICAL COMBINATIONS OF (S) -PANTOPRAZOLE WITH NSAID OR CORTICOSTEROIDS | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | WO | claimed |
| WO-2004071391-A2 | IMIDAZOPYRIDINES CONTAINING COMBINATIONS AND THEIR USE IN TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | ALTANA PHARMA AG (DE) | 2004-08-26 | — | — | WO | claimed |