SCHEMBL2732869

SCHEMBL2732869

CCCCc1nc2nc(NCO)[nH]c(=O)c2[nH]1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
XDH P47989 3/20 0.46
POLA1 P09884 1/20 0.40
PI4KA P42356 1/20 0.40
PI4K2B Q8TCG2 1/20 0.40
PI4K2A Q9BTU6 1/20 0.40
PI4KB Q9UBF8 1/20 0.40
PARP1 P09874 1/20 0.38
GPR84 Q9NQS5 5/20 0.37
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36
PNP P00491 1/20 0.35
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9059982 0.85 XDH (0.43) XDHPOLA1PI4KAPI4K2BPI4K2A
SCHEMBL7809880 0.84 XDH (0.61) XDHPOLA1PI4KAPI4K2BPI4K2A
SCHEMBL7862549 0.76 PBK (0.36) XDHALDH1A1PNP
SCHEMBL6272728 0.76 PNP (0.58) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL8522269 0.71 PNP (0.56) PI4KAPI4K2BPI4K2API4KBGPR84
SCHEMBL8536005 0.70 PNP (0.54) PI4KAPI4K2BPI4K2API4KBGPR84
SCHEMBL6272296 0.70 PNP (0.54) PI4KAPI4K2BPI4K2API4KBGPR84
SCHEMBL7777164 0.70 PNP (0.54) PI4KAPI4K2BPI4K2API4KBGPR84
SCHEMBL4384740 0.69 XDH (0.67) XDHPOLA1GPR84ALDH1A1PNP
Hydrochloric Acid SCHEMBL258896 0.69 PNP (0.53) PI4KAPI4K2BPI4K2API4KBGPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210147502-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2021-05-20 US disclosed
US-20200384135-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2020-12-10 US disclosed
EP-3004153-B1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2019-10-30 EP disclosed
US-10166300-B2 Tripartite cancer theranostic nucleic acid constructs VIRGINIA COMMONWEALTH UNIVERSITY (US) 2019-01-01 US disclosed
US-20180305429-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE UNIV VIRGINIA COMMONWEALTH (US) 2018-10-25 US disclosed
US-9951114-B2 Recombinant cancer therapeutic cytokine VIRGINIA COMMONWEALTH UNIVERSITY (US) 2018-04-24 US disclosed
EP-3003022-B1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS UNIV VIRGINIA COMMONWEALTH (US) 2017-11-22 EP disclosed
EP-3004872-B1 MDA-9/SYNTENIN PROMOTER TO IMAGE AND TREAT METASTATIC CANCER CELLS UNIV VIRGINIA COMMONWEALTH (US) 2017-10-18 EP disclosed
US-9750823-B2 Use of a truncated CCN1 promoter for cancer diagnostics, therapeutics and theranostics UNIV VIRGINIA COMMONWEALTH (US) 2017-09-05 US disclosed
US-9701985-B2 mda-9/syntenin promoter to image and treat metastatic cancer cells VIRGINIA COMMONWEALTH UNIVERSITY (US) 2017-07-11 US disclosed
EP-3003022-A1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS Virginia Commonwealth University (US) 2016-04-13 EP disclosed
WO-2014209553-A1 USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2014-12-31 WO disclosed
WO-2014197598-A2 TRIPARTITE CANCER THERANOSTIC NUCLEIC ACID CONSTRUCTS THE JOHNS HOPKINS UNIVERSITY (US) 2014-12-11 WO disclosed
WO-2014197535-A1 RECOMBINANT CANCER THERAPEUTIC CYTOKINE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2014-12-11 WO disclosed
US-20140227182-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS THE JOHNS HOPKINS UNIVERSITY (US) 2014-08-14 US disclosed
US-20130263296-A1 CANCER IMAGING WITH THERAPY: THERANOSTICS THE JOHNS HOPKINS UNIVERSITY (US) 2013-10-03 US disclosed
EP-2633063-A2 CANCER IMAGING WITH THERAPY: THERANOSTICS Virginia Commonwealth University (US) 2013-09-04 EP disclosed
WO-2012058522-A2 CANCER IMAGING WITH THERAPY: THERANOSTICS VIRGINIA COMMONWEALTH UNIVERSITY (US) 2012-05-03 WO disclosed
EP-1372664-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES Hollis-Eden Pharmaceuticals Inc. (US) 2004-01-02 EP disclosed
WO-2002069977-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES HOLLIS-EDEN PHARMACEUTICALS, INC. (US) 2002-09-12 WO disclosed