Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | BCR | P11274 | 1/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31660951 | 0.87 | CD274 (0.51) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL8798290 | 0.87 | SMN1; SMN2 (0.59) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL27320743 | 0.85 | ABL1 (0.57) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL8799831 | 0.85 | LMNA (0.58) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL31660945 | 0.85 | SMN1; SMN2 (0.61) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL12486547 | 0.83 | ABL1 (0.73) | ABL1BCRPIK3CBNPC1RAB9A | |
| SCHEMBL27335946 | 0.82 | PIK3CB (0.59) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL27335948 | 0.82 | ABL1 (0.54) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL30818892 | 0.82 | PIK3CB (0.58) | ABL1BCRPIK3CBNPC1ALDH1A1 | |
| SCHEMBL30818807 | 0.82 | PIK3CB (0.58) | ABL1BCRPIK3CBNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |