Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31660945 | 0.98 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9ATSHRRECQL | |
| SCHEMBL31660951 | 0.88 | CD274 (0.51) | SMN1; SMN2NPC1RAB9ATSHRCD274 | |
| SCHEMBL27330852 | 0.87 | ABL1 (0.66) | NPC1RAB9ARECQLPIK3CBABL1 | |
| SCHEMBL14421264 | 0.85 | CD274 (0.55) | SMN1; SMN2NPC1RAB9ATSHRRECQL | |
| SCHEMBL27741343 | 0.85 | CD274 (0.55) | SMN1; SMN2NPC1RAB9ATSHRRECQL | |
| SCHEMBL27332171 | 0.84 | ADORA3 (0.53) | SMN1; SMN2RAB9ACD274SCN9AALDH1A1 | |
| SCHEMBL27334586 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9ACD274ABL1 | |
| SCHEMBL14421382 | 0.82 | CCNE1 (0.56) | SMN1; SMN2NPC1RAB9ATSHRRECQL | |
| SCHEMBL27318007 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9ATSHRRECQL | |
| SCHEMBL4865217 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ACD274ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |