Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL28344709 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL28548371 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL28901683 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL26605130 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL273312 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Benzene SCHEMBL2367770 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL15647489 | 0.97 | TSHR (0.56) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL28958471 | 0.97 | TSHR (0.56) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL1652035 | 0.97 | TSHR (0.56) | NAPRTTSHRTDP1CA2CA4 | |
| Pyridine SCHEMBL27510816 | 0.97 | TSHR (0.56) | NAPRTTSHRTDP1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 387 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124184-A1 | ONCE DAILY ALDOSTERONE SYNTHASE INHIBITOR (R)-(+)-5-(P-CYANOPHENYL)-5,6,7,8-TETRAHYDROIMIDAZO[L,5-A]PYRIDINE | DAMIAN PHARMA AG (CH) | 2026-05-07 | — | — | US | claimed |
| EP-3822259-B1 | METHOD FOR SYNTHESIZING VALSARTAN | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2025-08-27 | — | — | EP | claimed |
| CN-120018847-A | Once daily aldosterone synthase inhibitor (R) - (+) -5- (p-cyanophenyl) -5,6,7, 8-tetrahydroimidazo [ L,5-A ] pyridine | 达米安制药股份公司 | 2025-05-16 | — | — | CN | claimed |
| US-20250129071-A1 | ALDOSTERONE SYNTHASE INHIBITOR | DAMIAN PHARMA AG (CH) | 2025-04-24 | — | — | US | claimed |
| US-12202827-B2 | Aldosterone synthase inhibitor | DAMIAN PHARMA AG (CH) | 2025-01-21 | — | — | US | claimed |
| CN-117736698-B | Large-size silicon wafer grinding fluid with high removal rate and low scratch, and preparation method and application thereof | 江苏奥首材料科技有限公司 | 2024-12-10 | — | — | CN | claimed |
| CN-118546265-A | Cellulose aldehyde and preparation method and application thereof | 新疆农业大学 | 2024-08-27 | — | — | CN | claimed |
| US-20240269119-A1 | R-FADROZOLE FOR USE IN THE TREATMENT OF ALDOSTONERISM | DAMIAN PHARMA AG (CH) | 2024-08-15 | — | — | US | claimed |
| CN-113543706-B | Electrode comprising a conductive acrylate-based pressure sensitive adhesive | 汉高股份有限及两合公司 | 2024-07-23 | — | — | CN | claimed |
| CN-118235027-A | Ion conductive composition for thermal sensor | 汉高股份有限及两合公司 | 2024-06-21 | — | — | CN | claimed |
| CN-107698620-A | A kind of deuterated thieno piperidine derivative, preparation method and applications | 江苏天士力帝益药业有限公司 | 2018-02-16 | — | — | CN | claimed |
| CN-106317402-A | Polyether monomer and preparation method and application thereof | 浙江皇马科技股份有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-105873926-A | 6-fluoro-2- [4- (pyridin-2-yl) but-3-yn-1-yl ] imidazo [1,2A ] pyridine monophosphate and polymorphs thereof as negative allosteric modulators of MGLU5 receptor | 阿德克斯法尔马股份公司 | 2016-08-17 | — | — | CN | claimed |
| CN-105566266-A | 15-ketone preparation method | NORTHEAST PHARMACEUTICAL GROUP CO LTD | 2016-05-11 | — | — | CN | claimed |
| CN-102531915-B | Method for preparing ethylene diamine through condensation and ammoniation by using bronsted acid ion liquid to catalyze ethanolamine | HUAIBEI KEDA CHEMICAL CO LTD | 2013-08-07 | — | — | CN | claimed |
| CN-102531915-A | Method for preparing ethylene diamine through condensation and ammoniation by using bronsted acid ion liquid to catalyze ethanolamine | HUAIBEI KEDA CHEMICAL CO LTD | 2012-07-04 | — | — | CN | claimed |
| CN-101092478-A | Method for preparing alkyl polyethenoxy ether acrylic ester, or alkyl polyethenoxy ether methyl acrylic ester | HAICHUAN IND CO LTD (CN) | 2007-12-26 | — | — | CN | claimed |
| CN-1203073-C | Fused imidazopyridine derivatives, process for producing the same and crystalline forms | SHIONOGI & CO (JP) | 2005-05-25 | — | — | CN | claimed |
| CN-1169818-C | 3-cyano-3-hydroxy pyridine phosphate ester and its synthetic method and use | 中国科学院上海有机化学研究所 | 2004-10-06 | — | — | CN | claimed |
| CN-1419557-A | Novel process for producing fused imidazopridine derivative and novel crystal form | SHIONOGI & CO (JP) | 2003-05-21 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240269119-A1 | R-FADROZOLE FOR USE IN THE TREATMENT OF ALDOSTONERISM | CYP21A2, NR5A1, CYP17A1 | NAPRT 1209/4885TSHR 1176/4885TDP1 2490/4885 |
| US-20260124184-A1 | ONCE DAILY ALDOSTERONE SYNTHASE INHIBITOR (R)-(+)-5-(P-CYANOPHENYL)-5,6,7,8-TETRAHYDROIMIDAZO[L,5-A]PYRIDINE | CYP21A2, NR3C2, CYP17A1 | NAPRT 1185/4885TSHR 1483/4885TDP1 1206/4885 |
| US-20250129071-A1 | ALDOSTERONE SYNTHASE INHIBITOR | CYP21A2, CYP17A1, CYP11B1 | NAPRT 481/4885TSHR 2406/4885TDP1 2537/4885 |
| US-12202827-B2 | Aldosterone synthase inhibitor | CYP21A2, CYP17A1, CYP11B1 | NAPRT 481/4885TSHR 2406/4885TDP1 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.