SCHEMBL27332575

SCHEMBL27332575

Cc1cccc(C(F)(F)F)c1COc1ccc(-n2cnc(CN)c2)nc1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.36
GRM5 P41594 1/20 0.32
FFAR1 O14842 1/20 0.32
PPARG P37231 1/20 0.31
RORC P51449 1/20 0.31
CPB1 P15086 1/20 0.31
CPB2 Q96IY4 1/20 0.31
NR1H2 P55055 1/20 0.30
NR1H3 Q13133 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30723622 0.90 NR1H2 (0.36) MAOBGRM5FFAR1PPARGRORC
SCHEMBL27331560 0.90 NR1H2 (0.36) MAOBGRM5FFAR1PPARGRORC
SCHEMBL27331561 0.84 NR1H2 (0.33) NR1H2NR1H3
SCHEMBL30723655 0.78 RORC (0.39) PPARGRORC
SCHEMBL27331457 0.78 RORC (0.39) PPARGRORC
SCHEMBL31373402 0.78 NR1H2 (0.35) PPARGRORCNR1H2NR1H3
SCHEMBL27331558 0.78 NR1H2 (0.35) PPARGRORCNR1H2NR1H3
SCHEMBL30723682 0.75 NOTUM (0.42) NR1H2NR1H3
SCHEMBL30723643 0.74 P2RX7 (0.36) MAOBFFAR1NR1H2NR1H3
SCHEMBL27332458 0.74 P2RX7 (0.36) MAOBFFAR1NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023235384-A1 COMPOUNDS FOR ENHANCING READ THROUGH OF GENES CONTAINING PREMATURE TERMINATION CODONS AND METHODS FOR MAKING AND USING THE SAME SANOFI US SERVICES INC. (US) 2023-12-07 WO disclosed