Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL721753 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1TDP1TSHR | |
| Ethylenediamine SCHEMBL6232364 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1TDP1TSHR | |
| Ethylenediamine SCHEMBL28858090 | 1.00 | CA5A (0.61) | CA5ACA5BALDH1A1TDP1TSHR | |
| Ethylenediamine SCHEMBL723589 | 1.00 | — | — | |
| Ethylenediamine SCHEMBL4419318 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL11236240 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL6157507 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL28246966 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL4419325 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL8214214 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5485722-A | Catalytic decomposition of hydroxylammonium nitrate-based monopropellants | OLIN CORPORATION (US) | 1996-01-23 | — | — | US | claimed |
| EP-2158395-B1 | HYDROXY AMINE BASED STAGED COMBUSTION HYBRID ROCKET MOTOR | RAYTHEON CO (US) | 2018-06-20 | — | — | EP | disclosed |
| EP-2714264-B1 | CATALYST, GAS GENERATOR, AND THRUSTER WITH IMPROVED THERMAL CAPABILITY AND CORROSION RESISTANCE | AEROJET ROCKETDYNE INC (US) | 2018-05-02 | — | — | EP | disclosed |
| US-20120304620-A1 | CATALYST, GAS GENERATOR, AND THRUSTER WITH IMPROVED THERMAL CAPABILITY AND CORROSION RESISTANCE | AEROJET-GENERAL CORPORATION (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2012166335-A1 | CATALYST, GAS GENERATOR, AND THRUSTER WITH IMPROVED THERMAL CAPABILITY AND CORROSION RESISTANCE | AEROJET-GENERAL CORPORATION (US) | 2012-12-06 | — | — | WO | disclosed |
| US-7966805-B2 | Hydroxyl amine based staged combustion hybrid rocket motor | RAYTHEON COMPANY (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090211227-A1 | Hydroxyl Amine Based Staged Combustion Hybrid Rocket Motor | RAYTHEON COMPANY | 2009-08-27 | — | — | US | disclosed |
| US-5485722-A | Catalytic decomposition of hydroxylammonium nitrate-based monopropellants | OLIN CORPORATION (US) | 1996-01-23 | — | — | US | disclosed |