Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27632292 | 0.90 | TDP1 (0.46) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL7033341 | 0.78 | ALDH1A1 (0.42) | TDP1L3MBTL1ALDH1A1CYP19A1MAPT | |
| SCHEMBL27203391 | 0.78 | ALDH1A1 (0.36) | TDP1ALDH1A1CYP19A1MAPT | |
| SCHEMBL20797428 | 0.77 | TDP1 (0.46) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL27759581 | 0.75 | TUBB1 (0.33) | POLBHTTLMNAMAPK1 | |
| SCHEMBL27665453 | 0.75 | TUBB1 (0.35) | KDM4EHTTLMNAMAPK1 | |
| SCHEMBL29396391 | 0.74 | TDP1 (0.62) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL1179747 | 0.74 | TDP1 (0.62) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL14553753 | 0.74 | TDP1 (0.50) | TDP1L3MBTL1KDM4EPOLBCTDSP1 | |
| SCHEMBL30673293 | 0.73 | TDP1 (0.49) | TDP1L3MBTL1KDM4EPOLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047285-A | New phenyl pyrimidine ketone derivatives and preparation method thereof | ICI PLC (GB) | 1990-11-28 | — | — | CN | claimed |
| CN-107176951-A | A kind of carbamide compounds, its preparation method and its medical usage | 恩瑞生物医药科技（上海）有限公司 | 2017-09-19 | — | — | CN | disclosed |
| CN-102272105-B | enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds | 梅瑞尔公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-103483263-B | Arylpyrrol-2-yl cyanoethylamino compounds, process for their preparation and their use | MERIAL LTD. (US) | 2016-04-13 | — | — | CN | disclosed |
| CN-102414195-B | Fused heterocyclic compound and use thereof | SUMITOMO CHEMICAL CO | 2014-11-12 | — | — | CN | disclosed |
| CN-103483263-A | Arylpyrrol-2-yl cyanoethylamino compounds, process for their preparation and their use | MERIAL LTD | 2014-01-01 | — | — | CN | disclosed |
| CN-101743230-B | Arylpyrrol-2-yl cyanoethylamino compounds, process for their preparation and their use | MERIAL LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-102414195-A | Fused heterocyclic compound and use thereof | SUMITOMO CHEMICAL CO | 2012-04-11 | — | — | CN | disclosed |
| CN-102272105-A | enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds | — | 2011-12-07 | — | — | CN | disclosed |
| CN-101743230-A | Arylpyrrol-2-yl cyanoethylamino compounds, process for their preparation and their use | AVENTIS AGRICULTURE | 2010-06-16 | — | — | CN | disclosed |
| CN-101605758-A | Methods of treating hepatitis C | PTC THERAPEUTICS INC (US) | 2009-12-16 | — | — | CN | disclosed |
| CN-101541748-A | Methods for treating hepatitis C | PTC THERAPEUTICS INC (US) | 2009-09-23 | — | — | CN | disclosed |
| CN-101076334-A | Benzoureas having anti-diabetic activity | MERCK & CO INC (US) | 2007-11-21 | — | — | CN | disclosed |
| CN-1047285-A | New phenyl pyrimidine ketone derivatives and preparation method thereof | ICI PLC (GB) | 1990-11-28 | — | — | CN | disclosed |