Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14785751 | 0.82 | ALDH1A1 (0.56) | KCNJ1ALDH1A1TP53KMT2AHPGD | |
| SCHEMBL15825107 | 0.81 | KCNJ1 (0.52) | NOTUMKCNJ1ALDH1A1TP53KMT2A | |
| SCHEMBL2733939 | 0.81 | KCNJ1 (0.52) | KCNJ1ALDH1A1TP53KMT2AHPGD | |
| SCHEMBL2731717 | 0.78 | KCNJ1 (0.49) | KCNJ1ALDH1A1TP53KMT2AHPGD | |
| SCHEMBL1577897 | 0.76 | NOTUM (0.68) | NOTUMKCNJ1ALDH1A1LRRK2CA12 | |
| SCHEMBL2730327 | 0.74 | KMT2A (0.67) | NOTUMKCNJ1ALDH1A1KMT2AHPGD | |
| SCHEMBL2733700 | 0.73 | NOTUM (0.58) | NOTUMKCNJ1ALDH1A1TP53KMT2A | |
| SCHEMBL24436810 | 0.73 | KDM4E (0.46) | ALDH1A1HPGDTSHRPTGS2 | |
| SCHEMBL15825106 | 0.73 | KMT2A (0.71) | KCNJ1TP53KMT2APTGS2MAPT | |
| SCHEMBL8125656 | 0.71 | ALDH1A1 (0.58) | KCNJ1ALDH1A1TP53KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |