Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545927 | 0.87 | PIK3CD (0.52) | PIK3CDGPR119 | |
| SCHEMBL17527355 | 0.81 | BTK (0.46) | PIK3CD | |
| SCHEMBL17527353 | 0.81 | BTK (0.46) | PIK3CD | |
| SCHEMBL17545937 | 0.79 | PIK3CD (0.42) | PIK3CDGPR119 | |
| SCHEMBL18419032 | 0.74 | PIK3CD (0.49) | PIK3CDPIK3CA | |
| SCHEMBL17527387 | 0.74 | PIK3CD (0.49) | PIK3CDPIK3CA | |
| SCHEMBL17545942 | 0.73 | PIK3CD (0.46) | PIK3CD | |
| SCHEMBL27229000 | 0.73 | HMOX1 (0.36) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL27232412 | 0.73 | HMOX1 (0.36) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL12590749 | 0.72 | PKM (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |