Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of (2E)-Hexenoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DGKA | P23743 | 1/20 | 0.33 |
| ▸ | SELP | P16109 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | PTAFR | P25105 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL2733734 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1S1PR1KMT2AALDH1A1 | |
| (2E)-Hexenoic Acid SCHEMBL29128925 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1S1PR1KMT2ASELP | |
| (2E)-Hexenoic Acid SCHEMBL27795754 | 0.78 | LMNA (0.44) | MEN1KMT2A | |
| (2E)-Hexenoic Acid SCHEMBL27142199 | 0.78 | LMNA (0.44) | MEN1KMT2A | |
| (2E)-Hexenoic Acid SCHEMBL30119852 | 0.78 | LMNA (0.44) | MEN1KMT2A | |
| (2E)-Hexenoic Acid SCHEMBL29002244 | 0.76 | LPAR1 (0.42) | S1PR1SELPALDH1A1TMEM97LPAR1 | |
| Choline SCHEMBL6017026 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1S1PR1KMT2AALDH1A1 | |
| Lysophosphatidic Acid SCHEMBL23500519 | 0.72 | LPAR1 (0.66) | DGKAFAAHLPAR1 | |
| (2E)-Hexenoic Acid SCHEMBL28090410 | 0.72 | TAS1R3 (0.43) | MEN1KMT2ADGKAFAAHALDH1A1 | |
| (2E)-Hexenoic Acid SCHEMBL29010324 | 0.71 | P2RY10 (0.43) | SELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116133652-A | Method for preparing lipid nanoparticles | 摩登纳特斯有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-116133652-A | Method for preparing lipid nanoparticles | 摩登纳特斯有限公司 | 2023-05-16 | — | — | CN | disclosed |