Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27349064 | 0.82 | ALDH1A1 (0.40) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL27784437 | 0.79 | ERN1 (0.43) | MAPTALDH1A1PKMKDM4EKMT2A | |
| SCHEMBL7687461 | 0.79 | ALDH1A1 (0.49) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL538232 | 0.76 | SMN1; SMN2 (0.55) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL11518311 | 0.70 | GSK3B (0.57) | MAPTALDH1A1PKMKDM4EKMT2A | |
| SCHEMBL11322508 | 0.70 | ALDH1A1 (0.48) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL538711 | 0.68 | SMN1; SMN2 (0.54) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL538189 | 0.67 | SMN1; SMN2 (0.53) | MAPTGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL28294417 | 0.67 | ALDH1A1 (0.39) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL3296437 | 0.65 | ALDH1A1 (0.51) | MAPTALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044245-C | Tricyclic Dicarbonyl derivatives | HAFFMANN LA ROCHE AG F (DE) | 1999-07-21 | — | — | CN | disclosed |