Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.39 |
| ▸ | CFD | P00746 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27318793 | 0.83 | EGFR (0.67) | EGFRJAK3JAK2TNNI3KCFD | |
| SCHEMBL27332161 | 0.82 | JAK3 (0.58) | EGFRJAK3JAK2ABL1MEN1 | |
| SCHEMBL27345372 | 0.80 | EGFR (0.46) | EGFRJAK3TNNI3KCFDMEN1 | |
| SCHEMBL27338332 | 0.80 | EGFR (0.49) | EGFRJAK3JAK2TNNI3KCFD | |
| SCHEMBL27401062 | 0.80 | EGFR (0.49) | EGFRJAK3JAK2TNNI3KCFD | |
| SCHEMBL27339281 | 0.80 | HTR7 (0.52) | EGFRJAK3TNNI3KCFDMEN1 | |
| SCHEMBL27337227 | 0.80 | JAK3 (0.50) | EGFRJAK3JAK2TNNI3KCFD | |
| SCHEMBL27323503 | 0.79 | EGFR (0.45) | EGFRTHRBTNNI3KCFDMEN1 | |
| SCHEMBL2063772 | 0.79 | MEN1 (0.48) | EGFRJAK3ABL1BCRTNNI3K | |
| SCHEMBL27319709 | 0.79 | EGFR (0.58) | EGFRJAK3CFDMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |