Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.41 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.41 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
| ▸ | PTPRG | P23470 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348009 | 0.81 | KLKB1 (0.42) | MRGPRX4ALDH1A1KDM4ECTSBKLKB1 | |
| SCHEMBL27626650 | 0.80 | ALDH1A1 (0.57) | MRGPRX4ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL25279171 | 0.79 | ALDH1A1 (0.66) | ALDH1A1TDP1KDM4EPOLBMAPT | |
| SCHEMBL19043821 | 0.79 | EPHX2 (0.48) | MRGPRX4ALDH1A1KDM4ECTSBKLKB1 | |
| SCHEMBL13622158 | 0.78 | ALDH1A1 (0.59) | MRGPRX4ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL27843215 | 0.77 | PPARA (0.55) | ALDH1A1TDP1KDM4EPOLBMAPT | |
| SCHEMBL27902483 | 0.77 | ALDH1A1 (0.53) | MRGPRX4ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL844419 | 0.77 | CYP4F2 (0.61) | MRGPRX4ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL1245996 | 0.77 | CA2 (0.59) | MRGPRX4ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL5113001 | 0.77 | FOLH1 (0.57) | MRGPRX4ALDH1A1TP53TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060764-C | Ortho-substituted benzoylguanidine, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST GMBH (DE) | 2001-01-17 | — | — | CN | disclosed |
| CN-1161960-A | Ortho-substituted benzoylguanidine, preparation method, use as medicine or diagnostic reagent and medicine containing same | HOECHST GMBH (DE) | 1997-10-15 | — | — | CN | disclosed |
| CN-1160041-A | Ortho-substd. benzoyl guanidines, their preparing process and use as medicine and diagnostic reagent, and medicine contg. same | HOECHST AG (DE) | 1997-09-24 | — | — | CN | disclosed |