⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26950116 | 0.86 | PAOX (0.38) | — | |
| SCHEMBL25668219 | 0.84 | GAA (0.31) | — | |
| SCHEMBL23428769 | 0.83 | PAOX (0.44) | — | |
| SCHEMBL11709983 | 0.79 | — | — | |
| SCHEMBL13225487 | 0.79 | LMNA (0.43) | — | |
| SCHEMBL8851248 | 0.79 | CYP2C19 (0.39) | — | |
| SCHEMBL9414616 | 0.78 | PAOX (0.41) | — | |
| SCHEMBL12226422 | 0.77 | KDM4E (0.50) | — | |
| SCHEMBL24084024 | 0.77 | ALDH1A1 (0.30) | — | |
| SCHEMBL22821625 | 0.77 | LMNA (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086467-A1 | CELASTROL PROTEOLYSIS TARGETING CHIMERAS | THE GENERAL HOSPITAL CORPORATION (US) | 2023-05-19 | — | — | WO | disclosed |
| US-11078235-B2 | Cyclic peptide conjugates and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-20190092812-A1 | CYCLIC PEPTIDE CONJUGATES AND METHODS OF USE | UNIVERSITY OF FLORIDA REASEARCH FOUNDATION INCORPORATED | 2019-03-28 | — | — | US | disclosed |
| US-10011635-B2 | Cyclic peptide conjugates and methods of use | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20160251470-A1 | ZWITTERIONIC POLYSACCHARIDE POLYMERS HAVING ANTIFOULING, ANTIMICROBIAL AND OPTICAL TRANSPARENCY PROPERTIES | NATIONAL SCIENCE FOUNDATION | 2016-09-01 | — | — | US | disclosed |
| WO-2013051625-A1 | METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS | 日産化学工業株式会社 (JP) | 2013-04-11 | — | — | WO | disclosed |
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010140685-A1 | HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER | 日産化学工業株式会社 (JP) | 2010-12-09 | — | — | WO | disclosed |
| EP-1944300-A2 | Prodrugs of aspartyl protease inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2008-07-16 | — | — | EP | disclosed |
| CN-1053472-C | Oligonucleotides derived from the SOD family | HOFFMANN LA ROCHE (CH) | 2000-06-14 | — | — | CN | disclosed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| CN-1106405-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | CN | disclosed |