Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 9/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13448963 | 0.90 | DRD3 (0.58) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL21250682 | 0.84 | DRD3 (0.65) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL27310809 | 0.83 | HTR1A (0.71) | DRD2DRD3DRD1HTR1AKCNH2 | |
| SCHEMBL13448959 | 0.83 | DRD2 (0.66) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL2027865 | 0.83 | DRD3 (0.70) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL17898233 | 0.81 | DRD3 (0.53) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL13448989 | 0.78 | DRD2 (0.69) | DRD2DRD3DRD1DRD4HTR7 | |
| SCHEMBL13448958 | 0.77 | DRD3 (0.67) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL13449000 | 0.77 | DRD3 (0.77) | DRD2DRD3DRD1HTR1ADRD4 | |
| SCHEMBL13448967 | 0.77 | DRD3 (0.80) | DRD2DRD3DRD1HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101039907-B | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB | 2011-02-23 | — | — | CN | claimed |
| CN-101039907-A | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | CN | claimed |
| CN-102134214-B | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB | 2013-05-22 | — | — | CN | disclosed |
| CN-102134214-A | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA SWEDEN AB | 2011-07-27 | — | — | CN | disclosed |
| CN-101039907-B | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB | 2011-02-23 | — | — | CN | disclosed |
| CN-101039907-A | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | CN | disclosed |
| CN-1049654-C | Piperazine derivatives | DAIICHI SEIYAKU CO (JP) | 2000-02-23 | — | — | CN | disclosed |