Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29024434 | 0.85 | MME (0.49) | L3MBTL1 | |
| SCHEMBL20153838 | 0.83 | MMP1 (0.49) | — | |
| SCHEMBL8787113 | 0.77 | ALDH1A1 (0.49) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL12666720 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL2734812 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL8724389 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL2602049 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL28785280 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL6302437 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB | |
| SCHEMBL3725043 | 0.77 | ATM (0.63) | ATMALDH1A1CYP2C9CYP2C19THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056844-C | Dioxide pyrrolo-pyrrolo derivatives | HOFFMANN LA ROCHE (CH) | 2000-09-27 | — | — | CN | disclosed |
| CN-1136567-A | Dioxide pyrrolo-pyrrolo derivatives | HOFFMANN LA ROCHE (CH) | 1996-11-27 | — | — | CN | disclosed |