SCHEMBL27351069

SCHEMBL27351069

O=C(OCC(Cl)(Cl)Cl)C1CC1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.38
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
ALDH1A1 P00352 5/20 0.36
POLB P06746 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
HPGD P15428 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ADRB2 P07550 1/20 0.34
ADRB1 P08588 1/20 0.34
ADRB3 P13945 1/20 0.34
HSD11B1 P28845 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9755016 0.86 TSHR (0.42) MAPTCHRM2CHRM4CHRM1CHRM3
SCHEMBL27787983 0.77 MAPT (0.42) MAPTALDH1A1MEN1KMT2AADRB2
SCHEMBL6141219 0.77 RAB9A (0.43) MAPTALDH1A1MEN1KMT2AADRB2
SCHEMBL5793024 0.77 HTT (0.46) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL5319074 0.77 HTT (0.46) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL3009771 0.77 MAPT (0.57) MAPTCHRM1ALDH1A1POLBMEN1
SCHEMBL2375356 0.73 MAPT (0.60) MAPTALDH1A1MEN1KMT2A
SCHEMBL7508338 0.73
SCHEMBL8891623 0.73 MAPT (0.60) MAPTALDH1A1MEN1KMT2A
SCHEMBL4221 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1056828-C Preparation process for esters of 2,2-dimethyl 3-{(Z) 1-propenyl} cyclopropane carboxylic acid and intermediates ROUSSEL UCLAF (FR) 2000-09-27 CN disclosed
CN-1080915-A 2, the 2-dimethyl-3-[(Z)-the 1-propenyl]-cyclopropanecarboxylcompound and intermediates preparation thereof ROUSSEL UCLAF (FR) 1994-01-19 CN disclosed