Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1162073 | 0.87 | MEN1 (0.54) | ALDH1A1F2GLAHPGDMEN1 | |
| SCHEMBL1162127 | 0.85 | ALDH1A1 (0.40) | ALDH1A1F2GLAHPGDMEN1 | |
| SCHEMBL3209723 | 0.82 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP3A4CYP1A2MKNK1 | |
| SCHEMBL3500223 | 0.79 | MKNK1 (0.55) | CYP11B1CYP11B2CYP3A4CYP1A2MKNK1 | |
| SCHEMBL26698318 | 0.78 | CYP3A4 (0.53) | CYP11B1CYP11B2CYP3A4ALDH1A1F2 | |
| SCHEMBL26698288 | 0.78 | ALDH1A1 (0.54) | CYP3A4MKNK1MKNK2ALDH1A1F2 | |
| SCHEMBL12736324 | 0.78 | LMNA (0.53) | CYP3A4ALDH1A1F2GLAHPGD | |
| SCHEMBL14805758 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP3A4CYP1A2MKNK1 | |
| SCHEMBL13586886 | 0.77 | LMNA (0.46) | CYP3A4HPGDMEN1KMT2AHSD17B10 | |
| SCHEMBL414964 | 0.77 | LMNA (0.50) | CYP3A4HPGDMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080257-C | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | CN | disclosed |
| CN-1123545-A | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-29 | — | — | CN | disclosed |
| CN-1050191-A | New thiazole derivative, they the preparation method and contain their pharmaceutical composition | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-03-27 | — | — | CN | disclosed |