Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062043 | 1.00 | HCAR2 (0.53) | HCAR2KEAP1NFE2L2ATMALDH1A1 | |
| SCHEMBL23544811 | 0.92 | NFE2L2 (0.68) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| SCHEMBL23557517 | 0.92 | NFE2L2 (0.68) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| SCHEMBL28997788 | 0.87 | HCAR2 (0.42) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL11898397 | 0.86 | — | — | |
| SCHEMBL11898399 | 0.86 | — | — | |
| SCHEMBL25177277 | 0.80 | — | — | |
| SCHEMBL27855095 | 0.79 | — | — | |
| SCHEMBL7745504 | 0.77 | — | — | |
| SCHEMBL25056786 | 0.77 | AKT1 (0.42) | HCAR2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | claimed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | claimed |
| CN-115322100-A | Delta, epsilon-alkenyl ketone compound and preparation method and application thereof | 南京工业大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-106604916-B | Crystal form of potassium ion competitive acid retarder and preparation method thereof | 江苏豪森药业集团有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-110200903-A | With the liquid preparation of salt stable amine and organic acid | 武田药品工业株式会社 | 2019-09-06 | — | — | CN | disclosed |
| CN-109843869-A | 1- [(pyridin-3-yl-sulfonyl) -1H- pyrroles -3- base] methylamine derivative and its pharmaceutical composition and purposes | 江苏吉贝尔药业股份有限公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-108602772-A | Novel crystal form of 1- (5- (2, 4-difluorophenyl) -1- ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrole-3-yl) -N-methylmelamine salt | 株式会社大熊制药 | 2018-09-28 | — | — | CN | disclosed |
| CN-108602771-A | The new acid-addition salts of 1- (5- (2,4 difluorobenzene base) -1- ((3- fluorophenyls) sulfonyl) -4- methoxyl group -1H- pyrroles -3- bases)-N- methyl methylamines | 株式会社大熊制药 | 2018-09-28 | — | — | CN | disclosed |
| CN-107941946-A | Detection method of Vonoprazan fumarate | 中山奕安泰医药科技有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107778286-A | A kind of synthesis technique of Vonoprazan fumarate | 成都弘达药业有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-104926790-B | A kind of high-purity Vonoprazan Fumarate compounds and its intermediate, impurity and their preparation method | 江苏奥赛康药业股份有限公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-104582687-A | Liquid formulations of amines and organic acids stabilized with salts | TAKEDA PHARMACEUTICAL | 2015-04-29 | — | — | CN | disclosed |
| CN-102421753-B | Process for preparing azole compounds | TAKEDA PHARMACEUTICAL | 2014-12-31 | — | — | CN | disclosed |
| CN-104211618-A | Process for producing pyrrole compound | TAKEDA PHARMACEUTICAL | 2014-12-17 | — | — | CN | disclosed |
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | disclosed |
| CN-102743330-A | Pharmaceutical composition | TAKEDA PHARMACEUTICAL | 2012-10-24 | — | — | CN | disclosed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-102164581-A | Pharmaceutical composition | TAKEDA PHARMACEUTICAL | 2011-08-24 | — | — | CN | disclosed |
| CN-1067991-C | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 2001-07-04 | — | — | CN | disclosed |
| CN-1161328-A | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 1997-10-08 | — | — | CN | disclosed |