SCHEMBL27360660

SCHEMBL27360660

Cc1c(C)c([N+](=O)[O-])c(C)c2c1OC(C)(N1CCOCC1)C2C

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.35
MAPK1 P28482 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
MAPT P10636 2/20 0.34
NSD2 O96028 1/20 0.33
PKM P14618 1/20 0.31
KMT2A Q03164 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27378391 0.79
SCHEMBL27361840 0.73 CNR1 (0.31)
SCHEMBL8718272 0.65 SMN1; SMN2 (0.36) ALDH1A1MAPTPKMKMT2ASMN1; SMN2
SCHEMBL8712950 0.64 ALDH1A1 (0.32) ALDH1A1
SCHEMBL13805561 0.61 ALDH1A1 (0.31) ALDH1A1SMN1; SMN2
SCHEMBL8718473 0.61 ACHE (0.37) ALDH1A1MAPTKMT2A
SCHEMBL8712974 0.61 ALDH1A1 (0.34) ALDH1A1MAPTKMT2ASMN1; SMN2
SCHEMBL3932577 0.60
SCHEMBL8716319 0.59 NPSR1 (0.36) ALDH1A1NPSR1
SCHEMBL7592620 0.58 TDP1 (0.50) ALDH1A1PKMKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1071165-A Aminocoumaran derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-04-21 CN disclosed