Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 16/20 | 0.54 |
| ▸ | CDK2 | P24941 | 16/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 14/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 13/20 | 0.54 |
| ▸ | CDK4 | P11802 | 5/20 | 0.54 |
| ▸ | CCND3 | P30281 | 3/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CCND2 | P30279 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31475403 | 0.85 | CDK2 (0.57) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL27361395 | 0.80 | CDK2 (0.55) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL25123123 | 0.79 | CCNE1 (0.62) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL30836981 | 0.79 | CCNE1 (0.62) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL27358626 | 0.76 | CCND1 (0.54) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL27361558 | 0.71 | FGFR1 (0.36) | CCND1CDK4CCND3CCND2PIK3CA | |
| SCHEMBL19863603 | 0.71 | CCNE1 (1.00) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL27229160 | 0.71 | CCND1 (0.51) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL30837012 | 0.71 | CCND1 (0.51) | CCND1CDK2CCNE1CDK6CDK4 | |
| SCHEMBL29990907 | 0.70 | CDK2 (0.57) | CCND1CDK2CCNE1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |